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ResMarkerDB
Database of Biomarkers of response to monoclonal antibody therapy in breast and colorectal cancer
Biomarker:
AKT1 E17K
AKT1 E17K, BRAF WILD TYPE, KRAS WILD TYPE
AKT1 E17K: rs121434592
AKT2 OVEREXPRESSION
ANXA1 OVEREXPRESSION
ANXA1 OVEREXPRESSION, ARID1A AMPLIFICATION
ANXA1 OVEREXPRESSION, ARID1A ONCOGENIC MUTATION
ANXA11 R197C
ANXA11 R197C: rs1049550
ARAF S490T
AREG OVEREXPRESSION
AREG OVEREXPRESSION, EREG OVEREXPRESSION
AREG UNDEREXPRESSION, EREG UNDEREXPRESSION
ARID1A DELETION
ARID1A DELETION, ERBB2 AMPLIFICATION
ATN1 UNDEREXPRESSION, BRAF WILD TYPE, KRAS WILD TYPE
BIRC5 OVEREXPRESSION
BRAF AMPLIFICATION
BRAF AMPLIFICATION, BRAF V600E
BRAF D594G
BRAF D594G: rs121913338
BRAF G466V
BRAF G466V: rs121913351
BRAF G596V, NRAS G13R
BRAF MUTATION
BRAF NON-V600E MUTATION
BRAF V600
BRAF V600E
BRAF V600E MSI HIGH
BRAF V600E, EGFR AMPLIFICATION
BRAF V600E, EGFR AMPLIFICATION, EGFR S492R
BRAF V600E, EGFR G465R
BRAF V600E, KRAS A146T
BRAF V600E, KRAS A146T, KRAS A146V
BRAF V600E, KRAS AMPLIFICATION
BRAF V600E, KRAS G12D
BRAF V600E, KRAS G13D
BRAF V600E, KRAS WILD TYPE
BRAF V600E, MAP2K1 L115P
BRAF V600E, MAP2K1 V211D
BRAF V600E, MDM2 AMPLIFICATION, MET AMPLIFICATION
BRAF V600E, MET AMPLIFICATION
BRAF V600E, PIK3CA P449T
BRAF V600E, TP53 Q192K
BRAF V600X
BRAF WILD TYPE, KRAS WILD TYPE, NRAS WILD TYPE
BRAF WILD TYPE, KRAS WILD TYPE, NRAS WILD TYPE, PIK3CA WILD TYPE
BRAF WILD TYPE, KRAS WILD TYPE, PIK3CA MUTATION
CCND1 OVEREXPRESSION
EGFR AMPLIFICATION
EGFR AMPLIFICATION, EGFR S492R
EGFR EXPRESSION
EGFR EXPRESSION, KRAS WILD TYPE
EGFR G465E
EGFR G465R
EGFR G719S
EGFR G719S: rs28929495
EGFR G724S
EGFR G724S: rs1051753269
EGFR I491M
EGFR K467T
EGFR OVEREXPRESSION
EGFR R451C
EGFR R451C: rs377567759
EGFR R521K
EGFR R521K: rs2227983
EGFR S464L
EGFR S468R
EGFR S492R
EGFR S492R: rs1057519860
EPHB4 OVEREXPRESSION
ERBB2 AMPLIFICATION
ERBB2 AMPLIFICATION, ERBB2 L755S
ERBB2 AMPLIFICATION, ERBB2 L866M
ERBB2 AMPLIFICATION, ERBB2 T798M
ERBB2 AMPLIFICATION, ERBB3 OVEREXPRESSION
ERBB2 AMPLIFICATION, ERBB3 OVEREXPRESSION, PIK3CA E545K
ERBB2 AMPLIFICATION, FGF19 AMPLIFICATION, FGF3 AMPLIFICATION, FGF4 AMPLIFICATION
ERBB2 AMPLIFICATION, HGF AMPLIFICATION
ERBB2 AMPLIFICATION, IL6 OVEREXPRESSION, IL6R OVEREXPRESSION, PTEN DELETION
ERBB2 AMPLIFICATION, MET AMPLIFICATION
ERBB2 AMPLIFICATION, MUC4 OVEREXPRESSION
ERBB2 AMPLIFICATION, PIK3CA ACTIVATING MUTATION
ERBB2 AMPLIFICATION, PIK3CA C420R
ERBB2 AMPLIFICATION, PIK3CA E545K
ERBB2 AMPLIFICATION, PIK3CA H1047R
ERBB2 AMPLIFICATION, PIK3CA I391M
ERBB2 AMPLIFICATION, PIK3CA K111N
ERBB2 AMPLIFICATION, PIK3CA MUTATION
ERBB2 AMPLIFICATION, PIK3CA ONCOGENIC MUTATION
ERBB2 AMPLIFICATION, PTEN DELETION
ERBB2 AMPLIFICATION, PTEN MUTATION
ERBB2 AMPLIFICATION, PTEN ONCOGENIC MUTATION
ERBB2 AMPLIFICATION, PTEN UNDEREXPRESSION
ERBB2 AMPLIFICATION, RARA AMPLIFICATION
ERBB2 C311R
ERBB2 D769H
ERBB2 D769Y
ERBB2 G309A
ERBB2 G309E
ERBB2 G778_P780dup MUTATION
ERBB2 I655V
ERBB2 I655V: rs1136201
ERBB2 K753E
ERBB2 L755S
ERBB2 L755S: rs121913470
ERBB2 L768S
ERBB2 L866M
ERBB2 OVEREXPRESSION
ERBB2 OVEREXPRESSION, ERBB3 OVEREXPRESSION
ERBB2 OVEREXPRESSION, PIK3CA H1047R
ERBB2 OVEREXPRESSION, PIK3CA MUTATION
ERBB2 POSITIVE, ESR1 POSITIVE, PGR POSITIVE
ERBB2 R896C
ERBB2 S310F
ERBB2 S310F, ESR1 OVEREXPRESSION
ERBB2 S310F: rs1057519816
ERBB2 S310Y
ERBB2 T798M
ERBB2 V773L
ERBB2 V777L
ERBB2 V842I
ERBB3 G284R
ERBB3 G284R: rs1057519803
ERBB3 OVEREXPRESSION
ERBB3 OVEREXPRESSION, PIK3CA H1047R
ERBB4 NUCLEAR TRANSLOCATION
ERBB4 UNDEREXPRESSION
EREG OVEREXPRESSION
FBXW7 MUTATION
GNAS R201C
GNAS R201C: rs11554273
HGF OVEREXPRESSION
HRAS G13D
KRAS 117
KRAS 12
KRAS 13
KRAS 146
KRAS 59
KRAS 61
KRAS A146P
KRAS A146T
KRAS A146T: rs121913527
KRAS A59T
KRAS A59T: rs121913528
KRAS EXON 2
KRAS EXON 2 MUTATION
KRAS EXON 3
KRAS EXON 4
KRAS G12/G13
KRAS G12A
KRAS G12A: rs121913529
KRAS G12C
KRAS G12C: rs121913530
KRAS G12D
KRAS G12D, PIK3CA Q546R
KRAS G12D: rs121913529
KRAS G12D: rs121913529, PIK3CA Q546R: rs397517201
KRAS G12R
KRAS G12R: rs121913530
KRAS G12S
KRAS G12S: rs121913530
KRAS G12V
KRAS G12V: rs121913529
KRAS G12X
KRAS G12X, KRAS G13X, PIK3CA MUTATION
KRAS G13D
KRAS G13D, PIK3CA D549N, PIK3CA E545K
KRAS G13D, PIK3CA H1047R
KRAS G13X
KRAS MUTATION
KRAS MUTATION, PIK3CA E545K
KRAS MUTATION, PIK3CA H1047R
KRAS MUTATION, PIK3CA WILD TYPE
KRAS ONCOGENIC MUTATION
KRAS Q22*
KRAS Q61H
KRAS Q61H: rs17851045
KRAS WILD TYPE
KRAS WILD TYPE, RS2946834
LIFR D578N
LIFR D578N RS361863
LIFR D578N: rs3729740
LINS1 I29V
LINS1 I29V: rs11247226
MAP2K1 C121S
MAP2K1 F53L
MAP2K1 K57N
MAP2K1 K57T
MAP2K1 K57T: rs1057519909
MED1 MUTATION
MET AMPLIFICATION
MET OVEREXPRESSION
MIR-125A OVEREXPRESSION
MIR-126 OVEREXPRESSION
MIR-129 OVEREXPRESSION
MIR-152 OVEREXPRESSION
MIR-17 OVEREXPRESSION
MIR-182 OVEREXPRESSION
MIR-18A OVEREXPRESSION
MIR-190B UNDEREXPRESSION
MIR-199A OVEREXPRESSION
MIR-199B OVEREXPRESSION
MIR-19B OVEREXPRESSION
MIR-200C RESTORATION
MIR-203 OVEREXPRESSION
MIR-21 OVEREXPRESSION
MIR-210 OVEREXPRESSION
MIR-219-2 OVEREXPRESSION
MIR-221 OVEREXPRESSION
MIR-26A OVEREXPRESSION
MIR-27B OVEREXPRESSION
MIR-296 OVEREXPRESSION
MIR-29C OVEREXPRESSION
MIR-337 OVEREXPRESSION
MIR-339 OVEREXPRESSION
MIR-375 OVEREXPRESSION
MIR-377 UNDEREXPRESSION
MIR-378A OVEREXPRESSION
MIR-383 UNDEREXPRESSION
MIR-451 OVEREXPRESSION
MIR-498 UNDEREXPRESSION
MIR-516B UNDEREXPRESSION
MIR-542 UNDEREXPRESSION
MIR-595 UNDEREXPRESSION
MIR-609 UNDEREXPRESSION
MIR-619 UNDEREXPRESSION
MIR-640 OVEREXPRESSION
MIR-654 UNDEREXPRESSION
MIR-7-1 OVEREXPRESSION
MIR-768 OVEREXPRESSION
MIR-769 UNDEREXPRESSION
MIR-801 OVEREXPRESSION
MIR-99B OVEREXPRESSION
MIRLET-7B UNDEREXPRESSION
MIRLET-7D OVEREXPRESSION
MIRLET-7E UNDEREXPRESSION
MIRLET-7F-1 OVEREXPRESSION
NF1 MUTATION
NRAS 117
NRAS 12
NRAS 13
NRAS 146
NRAS 59
NRAS 61
NRAS EXON 2
NRAS EXON 3
NRAS EXON 4
NRAS G12D
NRAS G12D: rs121913237
NRAS G12V
NRAS MUTATION
NRAS Q179X
NRAS Q61
NRAS WILD TYPE
NRG1 OVEREXPRESSION
NT5E OVEREXPRESSION
PIK3CA E542K
PIK3CA E542K: rs121913273
PIK3CA E542V
PIK3CA E542V: rs1057519927
PIK3CA E545K
PIK3CA E545K: rs104886003
PIK3CA EXON 21 MUTATION
PIK3CA F930S
PIK3CA H1047R
PIK3CA H1047R: rs121913279
PIK3CA H1047X
PIK3CA K944N
PIK3CA K966E
PIK3CA MUTATION
PIK3CA ONCOGENIC MUTATION
PIK3CA R88Q
PIK3CA R88Q: rs121913287
PIK3CA V952A
PIK3CA V955G
PIK3CA V955I
PIK3CA WILD TYPE
PPP1R15A R251P
PPP1R15A R251P: rs557806
PPP1R1B TRUNCATION
PTEN BIALLELIC INACTIVATION
PTEN DELETION
PTEN OVEREXPRESSION
PTP4A3 OVEREXPRESSION
RS3130
RS444903
RS4975596
RS6220
RS7736074
SMAD4 MUTATION
TGFBR1 T204D
TP53 MUTATION
TP53 Q192K: TP53_g.12643C>A
TP53 WILD TYPE
UCA1 KNOCKDOWN
VEGFA UNDEREXPRESSION
VEGFD OVEREXPRESSION
WHRN V400A
WHRN V400A: rs2274159
YB-1 S102D
YES1 AMPLIFICATION, YES1 OVEREXPRESSION
Example: ERBB; MIR-21; rs104886003
Drug:
Bevacizumab
Cetuximab
Panitumumab
Pertuzumab
Trastuzumab
Trastuzumab Emtansine
5-fluorouracil, Bevacizumab, Irinotecan, L-Folinic Acid
5-fluorouracil, Irinotecan, Oxaliplatin, Panitumumab
AC (Doxorubicin and Cyclophosphamide), Anastrozole, Paclitaxel, Pertuzumab, Trastuzumab
AC (Doxorubicin and Cyclophosphamide), Letrozole, Paclitaxel, Pertuzumab, Trastuzumab
AC (Doxorubicin and Cyclophosphamide), Paclitaxel, Pertuzumab, Tamoxifen, Trastuzumab
AC (Doxorubicin and Cyclophosphamide), Paclitaxel, Pertuzumab, Trastuzumab, Exemestane
ARQ092, Trastuzumab
AZD-5363, Trastuzumab
Afatinib, Lapatinib, Trastuzumab
Afatinib, Trastuzumab
Alpelisib (BYL719), Cetuximab, Encorafenib (LGX818)
Alpelisib (BYL719), Dabrafenib, Panitumumab
Anastrozole, Carboplatin, Docetaxel, Trastuzumab
Anastrozole, Cyclophosphamide, Doxorubicin, Paclitaxel, Trastuzumab
BGB-283, Cetuximab
BI 882370, Cetuximab
Bevacizumab, Capecitabine
Bevacizumab, Capecitabine, Irinotecan
Bevacizumab, Capecitabine, Vemurafenib
Bevacizumab, Cetuximab
Bevacizumab, Cetuximab, FOLFIRI Regimen
Bevacizumab, FOLFIRI Regimen
Bevacizumab, Oxaliplatin
Bevacizumab, Sorafenib
Bevacizumab, Temsirolimus
Buparlisib (BKM-120), Cetuximab
Buparlisib (BKM-120), Lapatinib, Trastuzumab
Buparlisib (BKM-120), Pertuzumab
Buparlisib (BKM-120), Pertuzumab, Trastuzumab
Buparlisib (BKM-120), Trastuzumab
CDX-3379, Trastuzumab
CH-5132799, Trastuzumab
Cabozantinib, Panitumumab
Capecitabine, Cetuximab, Oxaliplatin
Capecitabine, Trastuzumab
Capecitabine, Trastuzumab, Tucatinib (ARRY-380)
Carboplatin, Docetaxel, Exemestane, Pertuzumab, Trastuzumab
Carboplatin, Docetaxel, Exemestane, Trastuzumab
Carboplatin, Docetaxel, Letrozole, Pertuzumab, Trastuzumab
Carboplatin, Docetaxel, Letrozole, Trastuzumab
Carboplatin, Docetaxel, Pertuzumab, Tamoxifen, Trastuzumab
Carboplatin, Docetaxel, Pertuzumab, Trastuzumab
Carboplatin, Docetaxel, Tamoxifen, Trastuzumab
Carboplatin, Docetaxel, Trastuzumab
Cetuximab, 5-fluorouracil
Cetuximab, Crizotinib
Cetuximab, Dabrafenib
Cetuximab, Dabrafenib, SCH772984
Cetuximab, Dabrafenib, Trametinib
Cetuximab, Dasatinib
Cetuximab, Dasatinib, FOLFOX
Cetuximab, Encorafenib (LGX818)
Cetuximab, Erlotinib, Gefitinib, Vemurafenib
Cetuximab, FOLFIRI Regimen
Cetuximab, FOLFOX
Cetuximab, Floxuridine, 5-fluorouracil, Irinotecan
Cetuximab, Gefitinib, Vemurafenib
Cetuximab, Irinotecan
Cetuximab, Irinotecan, Vemurafenib
Cetuximab, JNJ-38877605
Cetuximab, LSN3074753
Cetuximab, Lapatinib
Cetuximab, Lapatinib, Trastuzumab
Cetuximab, Lauric Acid
Cetuximab, Lenalidomide
Cetuximab, PLX4720
Cetuximab, Panitumumab
Cetuximab, Panitumumab, Sorafenib
Cetuximab, Panitumumab, Sym004
Cetuximab, Regorafenib
Cetuximab, SCH772984
Cetuximab, Selumetinib (AZD6244)
Cetuximab, Selumetinib (AZD6244), Vemurafenib
Cetuximab, Sorafenib
Cetuximab, Trametinib
Cetuximab, Vemurafenib
Cyclophosphamide, Doxorubicin, Exemestane, Paclitaxel, Trastuzumab
Cyclophosphamide, Doxorubicin, Letrozole, Paclitaxel, Trastuzumab
Cyclophosphamide, Doxorubicin, Paclitaxel, Pertuzumab, Trastuzumab
Cyclophosphamide, Doxorubicin, Paclitaxel, Tamoxifen, Trastuzumab
Cyclophosphamide, Doxorubicin, Paclitaxel, Trastuzumab
Dabrafenib, Panitumumab
Dabrafenib, Panitumumab, Trametinib
Dasatinib, Trastuzumab
Docetaxel, Pertuzumab, Trastuzumab
Docetaxel, Pertuzumab, Trastuzumab Emtansine
Entinostat, Lapatinib, Trastuzumab
Erlotinib, Gefitinib, Trastuzumab
Everolimus, Trastuzumab, Vinorelbine
FOLFIRI Regimen, Panitumumab
FOLFIRI Regimen, Ramucirumab
Fulvestrant, Pertuzumab, Trastuzumab
Gimeracil (TS-1), Trastuzumab
Irinotecan, Panitumumab
Irinotecan, Panitumumab, Vemurafenib
JNJ-38877605, Panitumumab
LJM716, Trastuzumab
LY294002, Trastuzumab
Lapatinib, Paclitaxel, Trastuzumab
Lapatinib, Pertuzumab, Trastuzumab
Lapatinib, Trastuzumab
MK2206, Trastuzumab
MM-302, Trastuzumab
Napabucasin (BBI-608), Panitumumab
Neratinib, Pertuzumab
Oxaliplatin, Trastuzumab
Paclitaxel, Pertuzumab, Trastuzumab
Palbociclib (PD0332991), Trastuzumab
Palbociclib, Trastuzumab
Panitumumab, Cabozantinib
Panitumumab, Rilotumumab
Panitumumab, Sorafenib
Panitumumab, Sym004
Panitumumab, Trametenib
Panitumumab, Trametinib
Panitumumab, Vemurafenib
Pertuzumab, Trastuzumab
S63845, Trastuzumab
Sunitinib, Trastuzumab
Tamoxifen, Trastuzumab
Tanespimycin, Trastuzumab
Trastuzumab, Afatinib, Lapatinib, Neratinib
Trastuzumab, Tretinoin
Trastuzumab, Tucatinib (ARRY-380)
Trastuzumab, XL147
Trastuzumab, XL147 (Pilaralisib)
Tucatinib (ARRY-380), Trastuzumab Emtansine
Vinorelbine or Paclitaxel, Everolimus, Trastuzumab
Example: Cetuximab; Capecitabine, Trastuzumab
Tumor:
Breast Adenocarcinoma
Breast Carcinoma
Colon Carcinoma
Colon Mucinous Adenocarcinoma
Colorectal Adenocarcinoma
Colorectal Carcinoma
Estrogen-Receptor Positive Breast Carcinoma
HER2 Positive Breast Carcinoma
Malignant Breast Neoplasm
Malignant Colon Neoplasm
Example: Breast; Colon Carcinoma
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